Two goals from Lionel Messi to be the turning point for Barcelona and a 2-0 deficit in the first leg against AC Milan with the Italian club's embarrassing 4-0 at the Camp Nou on Tuesday night.
These results as well as making Barcelona are unbeaten in 20 home games in the Champions League.
The Catalans wasted no time and scored the first goal in the fifth minute through Lionel Messi kicks. Two other goals were contributed by David Villa and Jordi Alba.
Barcelona became the first club in the Champions who made it back after losing two goals in the first leg without the benefit of an away goal.
"We will remember this moment for years," said Barca director Andoni Zubizarreta on Spanish television.
"Messi's two goals put us in a strong position, scored Villa Alba is very important and the desires of all people with the fourth goal," he added.
Meanwhile, Villa said the victory was very happy.
"Amazingly, we'll enjoy this win now and I do not care who the opponent we will face in the quarterfinals later," he said.
"We like this you forget the bad days that have passed. I prefer to think of this day, we deserve this and we have to think about the future."